Dendritic Cells and Homeostasis in the GIT

In the UK and EU millions of people suffer from some form of gastrointestinal (GI) disorder. The relatioship between gastrointestinal dysfunction and chronic disease is multifaceted, compelling and complex. It is clear that when the normal integrity of the GI tract is compromised, this can result in distant systemic complaints even in the absence of overt GI symptomology.

IFM’s GI Advanced Practice Module®

This course will supply you with the foundational background, insight and in depth clinical thinking to confidently work up and treat patients who may present with conditions, signs and symptoms indicative of gastrointestinal dysfunction.
We will discuss in detail the important laboratory evaluations to be considered, the appropriateclinical connections that must be made and the treatment approaches that should be used.

What you will learn

  1. Know the most important and reliable laboratory evaluations associated with gastrointestinal dysfunction, and be able to interpret those tests. Lab evaluation competency to include food allergy and sensitivity, protozoan infection, bacterial and fungal dysbiosis (including small bowel bacterial overgrowth, microbiology, and bacterial and fungal antibodies) gastrointestinal barrier integrity, and gastrointestinal inflammation (including HS-CRP, calprotectin and lactoferrin).
  2. Evaluate the relationship between systemic disease and gastrointestinal dysfunction to improve understanding of pathophysiology in patients with these issues. Explain the pathophysiology of impaired barrier integrity; identify diseases and dysfunctions associated with increased intestinal permeability; recognise the relationship between autoimmune disease and impaired barrier integrity and explain the pathophysiology of gastrointestinal dysregulation not related to permeability issues.
  3. Recognise and treat the most important antecedents and triggers of gastrointestinal dysfunction, including food allergy (IgE), food intolerance, food sensitivity (IgG), protozoan infection, bacterial dysbiosis, small bowel bacterial overgrowth, fungal dysbiosis, pancreatic insufficiency, hydrochloric acid insufficiency, bile acid insufficiency, nutritional deficiencies and nutritional excesses.
  4. Develop and organise individual treatment protocols using lifestyle, diet, nutraceuticals, pharmaceuticals and botanicals.
  5. Understand and be able to implement an elimination diet.
  6. Reframe the patient’s story in the context of the Functional Medicine Matrix Model and a patient-centered assessment, with incorporation of the concepts of antecedents, triggers, and mediators.
  7. Be able to reflect back to the patient using analogy and metaphor the idea of leaky gut or impaired intestinal permeability and dysbiosis.


In the last few years there has been a seismic shift in research relating to the gastrointestinal inhabitants. The recent publications entering the scientific literature from the extensive Human Microbiome Project have revealed that even healthy individuals differ remarkably in the microbes that occupy habitats such as the gut, skin and vagina. Much of this diversity remains unexplained, although diet, environment, host genetics and early microbial exposure have all been implicated.

Surprisingly, it turns out that we owe much of our biology and our individuality to the microbes that live on and in our bodies — a realisation that promises to radically alter the principles and practice of medicine, public health and basic science. This APMS will seek to explore how the information we already have available to us permits safe and effective interventions to mediate progression and risk of functional and pathological conditions.

[pullquote]This course is unbelievable. I have been working in this field for 8 + years and this module cleared up a lot of my questions and made me more aware of new things I don’t know and need to work on. – 2010 GI Module attendee[/pullquote]